Jennifer Saunders and Joanna Lumley are on the big screen as Eddy and Patsy, the two badly behaved and selfish women who love drinking, drugs, cigarettes, and fashion and dislike work, responsibility, and Eddy's daughter Saffy (Julia Sawalha). When Patsy and Eddy discover that Kate Moss is looking for new representation, they decide Eddy should try to become her new P.R., only to accidentally knock Moss into the Thames, presumibly to her death. Eddy and Patsy go into hiding in the south of France to avoid the fallout from the scandal.

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